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Evaluation of a New Recombinant K39 Rapid Diagnostic Test for Sudanese Visceral Leishmaniasis.

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dc.contributor Médecins sans Frontières-Holland, Amsterdam, The Netherlands. koert.ritmeijer@amsterdam.msf.org
dc.creator Ritmeijer, K
dc.creator Melaku, Y
dc.creator Mueller, M
dc.creator Kipngetich, S
dc.creator O'keeffe, C
dc.creator Davidson, R N
dc.date 2006-01
dc.date.accessioned 2017-01-31T07:09:20Z
dc.date.available 2017-01-31T07:09:20Z
dc.identifier Evaluation of a New Recombinant K39 Rapid Diagnostic Test for Sudanese Visceral Leishmaniasis. 2006, 74 (1):76-80 Am. J. Trop. Med. Hyg.
dc.identifier 0002-9637
dc.identifier 16407349
dc.identifier http://hdl.handle.net/10144/17289
dc.identifier http://fieldresearch.msf.org/msf/handle/10144/17289
dc.identifier The American Journal of Tropical Medicine and Hygiene
dc.identifier.uri http://dspace.mediu.edu.my:8181/xmlui/handle/10144/17289
dc.description A new rK39 rapid diagnostic dipstick test (DiaMed-IT-Leish) was compared with aspiration and a direct agglutination test (DAT) for diagnosis of visceral leishmaniasis (VL) in 201 parasitologically confirmed cases, 133 endemic controls, and in 356 clinical suspects in disease-endemic and -epidemic areas in Sudan. The sensitivity of the rK39 test in parasitologically confirmed VL cases was 90%, whereas the specificity in disease-endemic controls was 99%. The sensitivity of the DAT was 98%. In clinically suspected cases, the sensitivity of the rK39 test was 81% and the specificity was 97%. When compared with the diagnostic protocol based on the DAT and aspiration used by Médecins sans Frontières in epidemic situations, the positive predictive value was 98%, and the negative predictive value was 71%. This rK39 rapid diagnostic test is suitable for screening as well as diagnosis of VL. Further diagnostic work-up of dipstick-negative patients with clinically suspected VL is important. The ease and convenience of the dipstick test will allow decentralization and improved access to care in disease-endemic areas in Sudan.
dc.language en
dc.publisher Published by: American Society of Tropical Medicine and Hygiene
dc.relation http://www.ajtmh.org
dc.rights Archived on this site with the kind permission of the American Society of Tropical Medicine and Hygiene, www.astmh.org
dc.title Evaluation of a New Recombinant K39 Rapid Diagnostic Test for Sudanese Visceral Leishmaniasis.


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