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The Efficacy of Chloroquine for the Treatment of Acute, Uncomplicated, Plasmodium Falciparum Malaria in Laos.

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dc.contributor Epicentre, 8 rue Saint Sabin, 75011 Paris, France. jguthmann@epicentre.msf.org
dc.creator Guthmann, J P
dc.creator Kasparian, S
dc.creator Phetsouvanh, R
dc.creator Nathan, N
dc.creator Garcia, M
dc.creator Phompida, S
dc.creator Brockman, A
dc.creator Gastellu-Etchegorry, M
dc.creator Legros, D
dc.date 2002-09
dc.date.accessioned 2017-01-31T07:09:11Z
dc.date.available 2017-01-31T07:09:11Z
dc.identifier The Efficacy of Chloroquine for the Treatment of Acute, Uncomplicated, Plasmodium Falciparum Malaria in Laos. 2002, 96 (6):553-7 Ann. Trop. Med. Parasitol.
dc.identifier 0003-4983
dc.identifier 12396318
dc.identifier 10.1179/000349802125001654
dc.identifier http://hdl.handle.net/10144/17278
dc.identifier http://fieldresearch.msf.org/msf/handle/10144/17278
dc.identifier Annals of Tropical Medicine and Parasitology
dc.identifier.uri http://dspace.mediu.edu.my:8181/xmlui/handle/10144/17278
dc.description To assess the local efficacy of chloroquine for the treatment of acute, uncomplicated, Plasmodium falciparum malaria, children and adults from Sekong province (an area of Laos with a low intensity of transmission) were tested in a 28-day, in-vivo study. Complete data were collected from 88 of the 102 subjects enrolled between October 1999 and September 2000. After genotypic analysis to distinguish recrudescing infections from re-infections, 35 (39.7%, with a 95% confidence interval of 29.5%-50.7%) of these 88 patients were considered treatment failures. These results seriously question the use of chloroquine as the first-line treatment for P. falciparum malaria in the study area.
dc.language en
dc.publisher Published by: Maney Publishing
dc.relation http://www.maney.co.uk/journals/atmp
dc.rights Archived on this site with the kind permission of Maney Publishing
dc.title The Efficacy of Chloroquine for the Treatment of Acute, Uncomplicated, Plasmodium Falciparum Malaria in Laos.


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