| dc.contributor |
Epicentre, 42 bis, Boulevard Richard Lenoir, 75011 Paris, France. xderadigues@epicentre.msf.org |
|
| dc.creator |
de Radiguès, X |
|
| dc.creator |
Diallo, K I |
|
| dc.creator |
Diallo, M |
|
| dc.creator |
Ngwakum, P A |
|
| dc.creator |
Maiga, H |
|
| dc.creator |
Djimdé, A |
|
| dc.creator |
Sacko, M |
|
| dc.creator |
Doumbo, O |
|
| dc.creator |
Guthmann, J P |
|
| dc.date |
2006-11 |
|
| dc.date.accessioned |
2017-01-31T07:09:11Z |
|
| dc.date.available |
2017-01-31T07:09:11Z |
|
| dc.identifier |
Efficacy of chloroquine and sulfadoxine/pyrimethamine for the treatment of uncomplicated falciparum malaria in Koumantou, Mali. 2006, 100 (11):1013-8 Trans. R. Soc. Trop. Med. Hyg. |
|
| dc.identifier |
0035-9203 |
|
| dc.identifier |
16765395 |
|
| dc.identifier |
10.1016/j.trstmh.2006.03.004 |
|
| dc.identifier |
http://hdl.handle.net/10144/17277 |
|
| dc.identifier |
http://fieldresearch.msf.org/msf/handle/10144/17277 |
|
| dc.identifier |
Transactions of the Royal Society of Tropical Medicine and Hygiene |
|
| dc.identifier.uri |
http://dspace.mediu.edu.my:8181/xmlui/handle/10144/17277 |
|
| dc.description |
We report the results of an in vivo antimalarial efficacy study with chloroquine (CQ) and sulfadoxine/pyrimethamine (SP) conducted between 2003 and 2004 in Koumantou, southern Mali. A total of 244 children were included in the study; 210 children were followed-up for 28 days according to WHO recommendations, with PCR genotyping to distinguish late recrudescence from re-infection. Global failure proportions at Day 14, without taking into account re-infections, were 44.2% (95% CI 34.9-53.5%) in the CQ group and 2.0% (95% CI 0.0-4.8%) in the SP group. PCR-adjusted failure proportions at Day 28 were even higher in the CQ group (90.5% (95/105), 95% CI 84.8-96.2%) and relatively low in the SP group (7.0% (7/100), 95% CI 1.9-12.1%). These results show that CQ is no longer efficacious in Koumantou. The use of SP in monotherapy is likely to compromise its efficacy. We recommend the use of artemisinin-based combination therapy as first-line treatment for uncomplicated Plasmodium falciparum malaria in Koumantou. |
|
| dc.language |
en |
|
| dc.publisher |
Elsevier |
|
| dc.relation |
http://www.sciencedirect.com/science/journal/00359203 |
|
| dc.rights |
Archived on this site with the kind permission of Elsevier Ltd. and the Royal Society of Tropical Medicine and Hygiene, http://www.rstmh.org/transactions.asp |
|
| dc.title |
Efficacy of chloroquine and sulfadoxine/pyrimethamine for the treatment of uncomplicated falciparum malaria in Koumantou, Mali. |
|