| dc.contributor |
MSF-UK, London, UK. ingrid.van.den.broek@london.msf.org |
|
| dc.creator |
van den Broek, I |
|
| dc.creator |
Maung, U A |
|
| dc.creator |
Peters, A |
|
| dc.creator |
Liem, L |
|
| dc.creator |
Kamal, M |
|
| dc.creator |
Rahman, M |
|
| dc.creator |
Rahman, M |
|
| dc.creator |
Bangali, A M |
|
| dc.creator |
Das, S |
|
| dc.creator |
Barends, M |
|
| dc.creator |
Faiz, A M |
|
| dc.date |
2005-10 |
|
| dc.date.accessioned |
2017-01-31T07:09:11Z |
|
| dc.date.available |
2017-01-31T07:09:11Z |
|
| dc.identifier |
Efficacy of chloroquine + sulfadoxine--pyrimethamine, mefloquine + artesunate and artemether + lumefantrine combination therapies to treat Plasmodium falciparum malaria in the Chittagong Hill Tracts, Bangladesh. 2005, 99 (10):727-35 Trans. R. Soc. Trop. Med. Hyg. |
|
| dc.identifier |
0035-9203 |
|
| dc.identifier |
16095643 |
|
| dc.identifier |
10.1016/j.trstmh.2005.02.007 |
|
| dc.identifier |
http://hdl.handle.net/10144/17274 |
|
| dc.identifier |
http://fieldresearch.msf.org/msf/handle/10144/17274 |
|
| dc.identifier |
Transactions of the Royal Society of Tropical Medicine and Hygiene |
|
| dc.identifier.uri |
http://dspace.mediu.edu.my:8181/xmlui/handle/10144/17274 |
|
| dc.description |
Bangladesh faces growing levels of Plasmodium falciparum resistance to chloroquine (CQ) and sulfadoxine-pyrimethamine (SP). Alternative antimalarial therapies, particularly combination regimens, need to be considered. Therefore, the efficacy of three antimalarial combination therapies was assessed in Chittagong Hill Tracts. A total of 364 P. falciparum patients were recruited and randomly assigned to either CQ + SP, mefloquine + artesunate (MQ + AS) or lumefantrine + artemether (Coartem). Results showed that CQ + SP therapy was less effective than the two artemisinin-based combination therapies. The day 42 PCR-corrected efficacy rate was 62.4% for CQ + SP, 100% for MQ + AS and 97.1% for Coartem. Failures occurred at a shorter interval after CQ + SP treatment than after Coartem. The artemisinin-based therapies effectively prevented development of gametocytes, whereas CQ + SP did not. All three therapies were well tolerated, although reports of mild complaints during treatment appeared higher with MQ + AS. We conclude that CQ + SP is not a viable option for replacing CQ monotherapy as first-line P. falciparum treatment in this area of Bangladesh. A change to artemisinin-based combination therapy is recommended. Both Coartem and MQ + AS appear to be good options, effective in curing P. falciparum malaria and in preventing recrudescences following treatment. |
|
| dc.language |
en |
|
| dc.publisher |
Elsevier |
|
| dc.relation |
http://www.sciencedirect.com/science/journal/00359203 |
|
| dc.rights |
Archived on this site with the kind permission of Elsevier Ltd. and the Royal Society of Tropical Medicine and Hygiene, http://www.rstmh.org/transactions.asp |
|
| dc.title |
Efficacy of chloroquine + sulfadoxine--pyrimethamine, mefloquine + artesunate and artemether + lumefantrine combination therapies to treat Plasmodium falciparum malaria in the Chittagong Hill Tracts, Bangladesh. |
|