dc.contributor |
Manson's Unit, MSF -UK, 67-74 Saffron Hill, London EC1N, UK. ingrid.van.den.broek@london.msf.org |
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dc.creator |
van den Broek, I |
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dc.creator |
Amsalu, R |
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dc.creator |
Balasegaram, M |
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dc.creator |
Hepple, P |
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dc.creator |
Alemu, E |
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dc.creator |
Hussein, E B |
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dc.creator |
Al-Faith, M |
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dc.creator |
Montgomery, J |
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dc.creator |
Checchi, F |
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dc.date |
2005 |
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dc.date.accessioned |
2017-01-31T07:09:19Z |
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dc.date.available |
2017-01-31T07:09:19Z |
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dc.identifier |
Efficacy of two artemisinin combination therapies for uncomplicated falciparum malaria in children under 5 years, Malakal, Upper Nile, Sudan. 2005, 4 (1):14 Malar. J. |
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dc.identifier |
1475-2875 |
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dc.identifier |
15730557 |
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dc.identifier |
10.1186/1475-2875-4-14 |
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dc.identifier |
http://hdl.handle.net/10144/17267 |
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dc.identifier |
http://fieldresearch.msf.org/msf/handle/10144/17267 |
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dc.identifier |
Malaria Journal |
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dc.identifier.uri |
http://dspace.mediu.edu.my:8181/xmlui/handle/10144/17267 |
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dc.description |
BACKGROUND: The treatment for Plasmodium falciparum malaria in Sudan has been in process of change since 2003. Preceding the change, this study aimed to determine which artemisinin-based combination therapies is more effective to treat uncomplicated malaria in Malakal, Upper Nile, Sudan. METHODS: Clinical trial to assess the efficacy of 2 antimalarial therapies to treat P. falciparum infections in children aged 6-59 months, in a period of 42 days after treatment. RESULTS: A total of 269 children were followed up to 42 days. Artesunate plus Sulfadoxine/Pyrimethamine (AS+SP) and Artesunate plus Amodiaquine (AS+AQ) were both found to be efficacious in curing malaria infections by rapid elimination of parasites and clearance of fever, in preventing recrudescence and suppressing gametocytaemia. The combination of AS+SP appeared slightly more efficacious than AS+AQ, with 4.4% (4/116) versus 15% (17/113) of patients returning with malaria during the 6-week period after treatment (RR = 0.9, 95% CI 0.81-0.96). PCR analysis identified only one recrudescence which, together with one other early treatment failure, gave efficacy rates of 99.0% for AS+AQ (96/97) and 99.1% for AS+SP (112/113). However, PCR results were incomplete and assuming part of the indeterminate samples were recrudescent infections leads to an estimated efficacy ranging 97-98% for AS+SP and 88-95% for AS+AQ. CONCLUSION: These results lead to the recommendation of ACT, and specifically AS+SP, for the treatment of uncomplicated falciparum malaria in this area of Sudan. When implemented, ACT efficacy should be monitored in sentinel sites representing different areas of the country. |
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dc.language |
en |
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dc.publisher |
BioMed Central |
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dc.relation |
http://www.malariajournal.com |
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dc.rights |
Archived on this site by Open Access permission |
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dc.title |
Efficacy of two artemisinin combination therapies for uncomplicated falciparum malaria in children under 5 years, Malakal, Upper Nile, Sudan. |
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