المستودع الأكاديمي جامعة المدينة

Efficacy of two artemisinin combination therapies for uncomplicated falciparum malaria in children under 5 years, Malakal, Upper Nile, Sudan.

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dc.contributor Manson's Unit, MSF -UK, 67-74 Saffron Hill, London EC1N, UK. ingrid.van.den.broek@london.msf.org
dc.creator van den Broek, I
dc.creator Amsalu, R
dc.creator Balasegaram, M
dc.creator Hepple, P
dc.creator Alemu, E
dc.creator Hussein, E B
dc.creator Al-Faith, M
dc.creator Montgomery, J
dc.creator Checchi, F
dc.date 2005
dc.date.accessioned 2017-01-31T07:09:19Z
dc.date.available 2017-01-31T07:09:19Z
dc.identifier Efficacy of two artemisinin combination therapies for uncomplicated falciparum malaria in children under 5 years, Malakal, Upper Nile, Sudan. 2005, 4 (1):14 Malar. J.
dc.identifier 1475-2875
dc.identifier 15730557
dc.identifier 10.1186/1475-2875-4-14
dc.identifier http://hdl.handle.net/10144/17267
dc.identifier http://fieldresearch.msf.org/msf/handle/10144/17267
dc.identifier Malaria Journal
dc.identifier.uri http://dspace.mediu.edu.my:8181/xmlui/handle/10144/17267
dc.description BACKGROUND: The treatment for Plasmodium falciparum malaria in Sudan has been in process of change since 2003. Preceding the change, this study aimed to determine which artemisinin-based combination therapies is more effective to treat uncomplicated malaria in Malakal, Upper Nile, Sudan. METHODS: Clinical trial to assess the efficacy of 2 antimalarial therapies to treat P. falciparum infections in children aged 6-59 months, in a period of 42 days after treatment. RESULTS: A total of 269 children were followed up to 42 days. Artesunate plus Sulfadoxine/Pyrimethamine (AS+SP) and Artesunate plus Amodiaquine (AS+AQ) were both found to be efficacious in curing malaria infections by rapid elimination of parasites and clearance of fever, in preventing recrudescence and suppressing gametocytaemia. The combination of AS+SP appeared slightly more efficacious than AS+AQ, with 4.4% (4/116) versus 15% (17/113) of patients returning with malaria during the 6-week period after treatment (RR = 0.9, 95% CI 0.81-0.96). PCR analysis identified only one recrudescence which, together with one other early treatment failure, gave efficacy rates of 99.0% for AS+AQ (96/97) and 99.1% for AS+SP (112/113). However, PCR results were incomplete and assuming part of the indeterminate samples were recrudescent infections leads to an estimated efficacy ranging 97-98% for AS+SP and 88-95% for AS+AQ. CONCLUSION: These results lead to the recommendation of ACT, and specifically AS+SP, for the treatment of uncomplicated falciparum malaria in this area of Sudan. When implemented, ACT efficacy should be monitored in sentinel sites representing different areas of the country.
dc.language en
dc.publisher BioMed Central
dc.relation http://www.malariajournal.com
dc.rights Archived on this site by Open Access permission
dc.title Efficacy of two artemisinin combination therapies for uncomplicated falciparum malaria in children under 5 years, Malakal, Upper Nile, Sudan.


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