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Does One Size Fit All? Drug Resistance and Standard Treatments: Results of Six Tuberculosis Programmes in Former Soviet Countries.

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dc.contributor Médecins Sans Frontières, Paris, France. maryline.bonnet@geneva.msf.org
dc.creator Bonnet, M
dc.creator Sizaire, V
dc.creator Kebede, Y
dc.creator Janin, A
dc.creator Doshetov, D
dc.creator Mirzoian, B
dc.creator Arzumanian, A
dc.creator Muminov, T
dc.creator Iona, E
dc.creator Rigouts, L
dc.creator Rüsch-Gerdess, S
dc.creator Varaine, F
dc.date 2005-10
dc.date.accessioned 2017-01-31T07:09:14Z
dc.date.available 2017-01-31T07:09:14Z
dc.identifier Does One Size Fit All? Drug Resistance and Standard Treatments: Results of Six Tuberculosis Programmes in Former Soviet Countries. 2005, 9 (10):1147-54 Int. J. Tuberc. Lung Dis.
dc.identifier 1027-3719
dc.identifier 16229227
dc.identifier http://hdl.handle.net/10144/17241
dc.identifier http://fieldresearch.msf.org/msf/handle/10144/17241
dc.identifier International Journal of Tuberculosis and Lung Disease
dc.identifier.uri http://dspace.mediu.edu.my:8181/xmlui/handle/10144/17241
dc.description SETTING: After the collapse of the Soviet Union, countries in the region faced a dramatic increase in tuberculosis cases and the emergence of drug resistance. OBJECTIVE: To discuss the relevance of the DOTS strategy in settings with a high prevalence of drug resistance. DESIGN: Retrospective analysis of one-year treatment outcomes of short-course chemotherapy (SCC) and results of drug susceptibility testing (DST) surveys of six programmes located in the former Soviet Union: Kemerovo prison, Russia; Abkhasia, Georgia; Nagorno-Karabagh, Azerbaijan; Karakalpakstan, Uzbekistan; Dashoguz Velayat, Turkmenistan; and South Kazakhstan Oblast, Kazakhstan. Results are reported for new and previously treated smear-positive patients. RESULTS: Treatment outcomes of 3090 patients and DST results of 1383 patients were collected. Treatment success rates ranged between 87% and 61%, in Nagorno-Karabagh and Kemerovo, respectively, and failure rates between 7% and 23%. Any drug resistance ranged between 66% and 31% in the same programmes. MDR rates ranged between 28% in Karakalpakstan and Kemerovo prison and 4% in Nagorno-Karabagh. CONCLUSION: These results show the limits of SCC in settings with a high prevalence of drug resistance. They demonstrate that adapting treatment according to resistance patterns, access to reliable culture, DST and good quality second-line drugs are necessary.
dc.language en
dc.publisher International Union Against TB and Lung Disease
dc.relation http://www.ingentaconnect.com/content/iuatld/ijtld
dc.rights Archived on this site with the kind permission of the International Union Against TB and Lung Disease, http://www.iuatld.org
dc.title Does One Size Fit All? Drug Resistance and Standard Treatments: Results of Six Tuberculosis Programmes in Former Soviet Countries.


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