| dc.contributor |
Médecins Sans Frontières, Paris, France. maryline.bonnet@geneva.msf.org |
|
| dc.creator |
Bonnet, M |
|
| dc.creator |
Sizaire, V |
|
| dc.creator |
Kebede, Y |
|
| dc.creator |
Janin, A |
|
| dc.creator |
Doshetov, D |
|
| dc.creator |
Mirzoian, B |
|
| dc.creator |
Arzumanian, A |
|
| dc.creator |
Muminov, T |
|
| dc.creator |
Iona, E |
|
| dc.creator |
Rigouts, L |
|
| dc.creator |
Rüsch-Gerdess, S |
|
| dc.creator |
Varaine, F |
|
| dc.date |
2005-10 |
|
| dc.date.accessioned |
2017-01-31T07:09:14Z |
|
| dc.date.available |
2017-01-31T07:09:14Z |
|
| dc.identifier |
Does One Size Fit All? Drug Resistance and Standard Treatments: Results of Six Tuberculosis Programmes in Former Soviet Countries. 2005, 9 (10):1147-54 Int. J. Tuberc. Lung Dis. |
|
| dc.identifier |
1027-3719 |
|
| dc.identifier |
16229227 |
|
| dc.identifier |
http://hdl.handle.net/10144/17241 |
|
| dc.identifier |
http://fieldresearch.msf.org/msf/handle/10144/17241 |
|
| dc.identifier |
International Journal of Tuberculosis and Lung Disease |
|
| dc.identifier.uri |
http://dspace.mediu.edu.my:8181/xmlui/handle/10144/17241 |
|
| dc.description |
SETTING: After the collapse of the Soviet Union, countries in the region faced a dramatic increase in tuberculosis cases and the emergence of drug resistance. OBJECTIVE: To discuss the relevance of the DOTS strategy in settings with a high prevalence of drug resistance. DESIGN: Retrospective analysis of one-year treatment outcomes of short-course chemotherapy (SCC) and results of drug susceptibility testing (DST) surveys of six programmes located in the former Soviet Union: Kemerovo prison, Russia; Abkhasia, Georgia; Nagorno-Karabagh, Azerbaijan; Karakalpakstan, Uzbekistan; Dashoguz Velayat, Turkmenistan; and South Kazakhstan Oblast, Kazakhstan. Results are reported for new and previously treated smear-positive patients. RESULTS: Treatment outcomes of 3090 patients and DST results of 1383 patients were collected. Treatment success rates ranged between 87% and 61%, in Nagorno-Karabagh and Kemerovo, respectively, and failure rates between 7% and 23%. Any drug resistance ranged between 66% and 31% in the same programmes. MDR rates ranged between 28% in Karakalpakstan and Kemerovo prison and 4% in Nagorno-Karabagh. CONCLUSION: These results show the limits of SCC in settings with a high prevalence of drug resistance. They demonstrate that adapting treatment according to resistance patterns, access to reliable culture, DST and good quality second-line drugs are necessary. |
|
| dc.language |
en |
|
| dc.publisher |
International Union Against TB and Lung Disease |
|
| dc.relation |
http://www.ingentaconnect.com/content/iuatld/ijtld |
|
| dc.rights |
Archived on this site with the kind permission of the International Union Against TB and Lung Disease, http://www.iuatld.org |
|
| dc.title |
Does One Size Fit All? Drug Resistance and Standard Treatments: Results of Six Tuberculosis Programmes in Former Soviet Countries. |
|