| dc.contributor |
Médecins sans Frontières-Luxembourg, Thyolo District, Malawi. zachariah@internet.lu |
|
| dc.creator |
Zachariah, R |
|
| dc.creator |
Harries, A D |
|
| dc.creator |
Spielmann M P |
|
| dc.creator |
Arendt, V |
|
| dc.creator |
Nchingula, D |
|
| dc.creator |
Mwenda, R |
|
| dc.creator |
Courteille, O |
|
| dc.creator |
Kirpach, P |
|
| dc.creator |
Mwale, B |
|
| dc.creator |
Salaniponi, F M L |
|
| dc.date |
2008-01-31T15:06:04Z |
|
| dc.date.accessioned |
2017-01-31T07:09:14Z |
|
| dc.date.available |
2017-01-31T07:09:14Z |
|
| dc.identifier |
Changes in Escherichia coli resistance to co-trimoxazole in tuberculosis patients and in relation to co-trimoxazole prophylaxis in Thyolo, Malawi., 96 (2):202-4 Trans. R. Soc. Trop. Med. Hyg. |
|
| dc.identifier |
0035-9203 |
|
| dc.identifier |
12055816 |
|
| dc.identifier |
http://hdl.handle.net/10144/17237 |
|
| dc.identifier |
http://fieldresearch.msf.org/msf/handle/10144/17237 |
|
| dc.identifier |
Transactions of the Royal Society of Tropical Medicine and Hygiene |
|
| dc.identifier.uri |
http://dspace.mediu.edu.my:8181/xmlui/handle/10144/17237 |
|
| dc.description |
In Thyolo district, Malawi, an operational research study is being conducted on the efficacy and feasibility of co-trimoxazole prophylaxis in preventing deaths in HIV-positive patients with tuberculosis (TB). A series of cross-sectional studies were carried out in 1999 and 2001 to determine (i) whether faecal Escherichia coli resistance to co-trimoxazole in TB patients changed with time, and (ii) whether the resistance pattern was different in HIV-positive TB patients who were taking co-trimoxazole prophylaxis. Co-trimoxazole resistance among E. coli isolates in TB patients at the time of registration was 60% in 1999 and 77% in 2001 (P < 0.01). Resistance was 89% among HIV-infected TB patients (receiving cotrimoxazole), while in HIV-negative patients (receiving anti-TB therapy alone) it was 62% (P < 0.001). The study shows a significant increase of E. coli resistance to co-trimoxazole in TB patients which is particularly prominent in HIV-infected patients on co-trimoxazole prophylaxis. Since a high degree of plasmid-mediated transfer of resistance exists between E. coli and the Salmonella species, these findings could herald limitations on the short- and long-term benefits to be expected from the use of co-trimoxazole prophylaxis in preventing non-typhoid Salmonella bacteraemia and enteritis in HIV-infected TB patients in Malawi. |
|
| dc.language |
en |
|
| dc.publisher |
Elsevier |
|
| dc.relation |
http://www.sciencedirect.com/science/journal/00359203 |
|
| dc.rights |
Archived on this site with the kind permission of Elsevier Ltd. and the Royal Society of Tropical Medicine and Hygiene, http://www.rstmh.org/transactions.asp |
|
| dc.title |
Changes in Escherichia coli resistance to co-trimoxazole in tuberculosis patients and in relation to co-trimoxazole prophylaxis in Thyolo, Malawi. |
|