| dc.contributor |
Medecins Sans Frontieres |
|
| dc.creator |
Prabhat K. Sinha |
|
| dc.creator |
Paul Roddy |
|
| dc.creator |
Pedro Pablo Palma |
|
| dc.creator |
Alice Kociejowski |
|
| dc.creator |
María Angeles (Nines) Lima |
|
| dc.creator |
Vidya Nand Rabi Das |
|
| dc.creator |
Jitendra Gupta |
|
| dc.creator |
Nawin Kumar |
|
| dc.creator |
Gaurab Mitra |
|
| dc.creator |
Jean-François Saint-Sauveur |
|
| dc.creator |
Siju Seena |
|
| dc.creator |
Manica Balasegaram |
|
| dc.creator |
Fernando Parreño |
|
| dc.creator |
Krishna Pandey |
|
| dc.date |
2010-08 |
|
| dc.date.accessioned |
2017-01-31T07:18:10Z |
|
| dc.date.available |
2017-01-31T07:18:10Z |
|
| dc.identifier |
Am. J. Trop. Med. Hyg., 83(2), 2010, pp. 357–364 |
|
| dc.identifier |
00029637 |
|
| dc.identifier |
10.4269/ajtmh.2010.10-0156 |
|
| dc.identifier |
http://hdl.handle.net/10144/114066 |
|
| dc.identifier |
http://fieldresearch.msf.org/msf/handle/10144/114066 |
|
| dc.identifier |
American Journal of Tropical Medicine and Hygiene |
|
| dc.identifier.uri |
http://dspace.mediu.edu.my:8181/xmlui/handle/10144/114066 |
|
| dc.description |
We evaluated, through the prospective monitoring of 251 patients at Sadar Hospital in Bihar, India, the effectiveness and safety of 20 mg/kg body weight of liposomal amphotericin B for the treatment of visceral leishmaniasis. The treatment success rates for the intention-to-treat, per protocol, and intention-to-treat worse-case scenario analyses were 98.8%, 99.6%, and 81.3%, respectively. Nearly one-half of patients experienced mild adverse events, but only 1%
developed serious but non–life-threatening lips swelling. The lost to follow-up rate was 17.5%. Our findings indicate that the 20 mg/kg body weight treatment dosage is effective and safe under routine program conditions. Given that the exorbitant
cost of liposomal amphotericin B is a barrier to its widespread use, we recommend further study to monitor and evaluate a lowered dosage and a shorter treatment course. |
|
| dc.language |
en |
|
| dc.publisher |
The American Society of Tropical Medicine and Hygiene |
|
| dc.rights |
Published by: American Society of Tropical Medicine and Hygiene, [url]http://www.ajtmh.org[/url]
Archived on this site with the kind permission of the American Society of Tropical Medicine and Hygiene, [url]http://www.astmh.org[/url] |
|
| dc.title |
Effectiveness and Safety of Liposomal Amphotericin B for Visceral Leishmaniasis under Routine Program Conditions in Bihar, India |
|
| dc.type |
Article |
|