| dc.contributor |
Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand; Shoklo Malaria Research Unit, Mae Sot, Thailand; Menzies School of Health Research and Royal Darwin Hospital, Darwin, Australia; Division of Clinical Pharmacology, Department of Medicine, University |
|
| dc.creator |
Stepniewska, Kasia |
|
| dc.creator |
Ashley, Elizabeth |
|
| dc.creator |
Lee, Sue J |
|
| dc.creator |
Anstey, Nicholas |
|
| dc.creator |
Barnes, Karen I |
|
| dc.creator |
Binh, Tran Quang |
|
| dc.creator |
D'Alessandro, Umberto |
|
| dc.creator |
Day, Nicholas P J |
|
| dc.creator |
de Vries, Peter J |
|
| dc.creator |
Dorsey, Grant |
|
| dc.creator |
Guthmann, Jean-Paul |
|
| dc.creator |
Mayxay, Mayfong |
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| dc.creator |
Newton, Paul N |
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| dc.creator |
Olliaro, Piero |
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| dc.creator |
Osorio, Lyda |
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| dc.creator |
Price, Ric N |
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| dc.creator |
Rowland, Mark |
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| dc.creator |
Smithuis, Frank |
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| dc.creator |
Taylor, Walter R J |
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| dc.creator |
Nosten, François |
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| dc.creator |
White, Nicholas J |
|
| dc.date |
2010-01-19 |
|
| dc.date.accessioned |
2017-01-31T07:19:21Z |
|
| dc.date.available |
2017-01-31T07:19:21Z |
|
| dc.identifier |
J Infect Dis 2010;201(4):570-9 |
|
| dc.identifier |
1537-6613 |
|
| dc.identifier |
20085495 |
|
| dc.identifier |
10.1086/650301 |
|
| dc.identifier |
http://hdl.handle.net/10144/112694 |
|
| dc.identifier |
http://fieldresearch.msf.org/msf/handle/10144/112694 |
|
| dc.identifier |
The Journal of Infectious Diseases |
|
| dc.identifier.uri |
http://dspace.mediu.edu.my:8181/xmlui/handle/10144/112694 |
|
| dc.description |
Parasite clearance data from 18,699 patients with falciparum malaria treated with an artemisinin derivative in areas of low (n=14,539), moderate (n=2077), and high (n=2083) levels of malaria transmission across the world were analyzed to determine the factors that affect clearance rates and identify a simple in vivo screening measure for artemisinin resistance. The main factor affecting parasite clearance time was parasite density on admission. Clearance rates were faster in high-transmission settings and with more effective partner drugs in artemisinin-based combination treatments (ACTs). The result of the malaria blood smear on day 3 (72 h) was a good predictor of subsequent treatment failure and provides a simple screening measure for artemisinin resistance. Artemisinin resistance is highly unlikely if the proportion of patients with parasite densities of <100,000 parasites/microL given the currently recommended 3-day ACT who have a positive smear result on day 3 is <3%; that is, for n patients the observed number with a positive smear result on day 3 does not exceed (n + 60)/24. |
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| dc.language |
en |
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| dc.rights |
Published by Infectious Diseases Society of America
Archived on this site with permission and copyright 2010 by the Infectious Diseases Society of America, [url]http://www.journals.uchicago.edu/toc/jid[/url] |
|
| dc.title |
In vivo parasitological measures of artemisinin susceptibility |
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| dc.type |
Article |
|