Titration Microcalorimetry Study: Interaction of Drug and Ionic Microgel System

Please use this identifier to cite or link to this item: http://dspace.mediu.edu.my:8181/xmlui/handle/1721.1/3953

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DC Field	Value	Language
dc.creator	Tian, Y.	-
dc.creator	Tam, Michael K. C.	-
dc.creator	Hatton, T. Alan	-
dc.creator	Bromberg, Lev	-
dc.date	2003-12-16T14:34:33Z	-
dc.date	2003-12-16T14:34:33Z	-
dc.date	2004-01	-
dc.date.accessioned	2013-10-09T02:33:18Z	-
dc.date.available	2013-10-09T02:33:18Z	-
dc.date.issued	2013-10-09	-
dc.identifier	http://hdl.handle.net/1721.1/3953	-
dc.identifier.uri	http://koha.mediu.edu.my:8181/xmlui/handle/1721	-
dc.description	Doxorubicin (DOX) and Pluronic-PAA interaction was investigated using isothermal titration calorimetry (ITC). DOX/polymer interaction is governed primarily by electrostatic interaction. The uptake of DOX results in the formation of insoluble polymer/DOX complex. Addition of salt weakens the interaction of drug and polymer by charge shielding effect between positive ionized amino group on DOX and oppositely charged polymer chains. However high drug-loading capacity in high salt condition implied that self-association property of DOX also play a role in the drug loading process.	-
dc.description	Singapore-MIT Alliance (SMA)	-
dc.format	217967 bytes	-
dc.format	application/pdf	-
dc.language	en_US	-
dc.relation	Molecular Engineering of Biological and Chemical Systems (MEBCS);	-
dc.subject	anticancer drug	-
dc.subject	ionic microgel	-
dc.subject	electrostatic interaction	-
dc.subject	hydrophobic interaction	-
dc.title	Titration Microcalorimetry Study: Interaction of Drug and Ionic Microgel System	-
dc.type	Article	-
Appears in Collections:	MIT Items

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