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http://dspace.mediu.edu.my:8181/xmlui/handle/1721.1/3952| Title: | Synthesis and Properties of Novel Cationic, Temperature-Sensitive Block-Copolymers |
| Keywords: | poly(2-N-(dimethylaminoethyl) methacrylate) Pluronic® cerium (IV) free-radical polymerization self-assembly gene therapy |
| Issue Date: | 9-Oct-2013 |
| Description: | Facile, one-step synthesis of self-assembling, cationic block copolymers of poly(2-N-(dimethylaminoethyl) methacrylate) (pDMAEMA) and PEO-PPO-PEO (Pluronic®) is developed. The copolymers are obtained via free-radical polymerization of DMAEMA initiated by Pluronic-radicals generated by cerium (IV). The copolymers possess surface activity, are polycationic at pH<7.1, and self-assemble into micelle-like aggregates when neutralized. Potential applications of the novel copolymers for DNA transfection in gene therapy are discussed. Singapore-MIT Alliance (SMA) |
| URI: | http://koha.mediu.edu.my:8181/xmlui/handle/1721 |
| Other Identifiers: | http://hdl.handle.net/1721.1/3952 |
| Appears in Collections: | MIT Items |
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