Synthesis and Properties of Novel Cationic, Temperature-Sensitive Block-Copolymers

Please use this identifier to cite or link to this item: http://dspace.mediu.edu.my:8181/xmlui/handle/1721.1/3952

Full metadata record

DC Field	Value	Language
dc.creator	Deshmukh, Smeet	-
dc.creator	Bromberg, Lev	-
dc.creator	Hatton, T. Alan	-
dc.date	2003-12-16T14:30:52Z	-
dc.date	2003-12-16T14:30:52Z	-
dc.date	2004-01	-
dc.date.accessioned	2013-10-09T02:33:18Z	-
dc.date.available	2013-10-09T02:33:18Z	-
dc.date.issued	2013-10-09	-
dc.identifier	http://hdl.handle.net/1721.1/3952	-
dc.identifier.uri	http://koha.mediu.edu.my:8181/xmlui/handle/1721	-
dc.description	Facile, one-step synthesis of self-assembling, cationic block copolymers of poly(2-N-(dimethylaminoethyl) methacrylate) (pDMAEMA) and PEO-PPO-PEO (Pluronic®) is developed. The copolymers are obtained via free-radical polymerization of DMAEMA initiated by Pluronic-radicals generated by cerium (IV). The copolymers possess surface activity, are polycationic at pH<7.1, and self-assemble into micelle-like aggregates when neutralized. Potential applications of the novel copolymers for DNA transfection in gene therapy are discussed.	-
dc.description	Singapore-MIT Alliance (SMA)	-
dc.format	335893 bytes	-
dc.format	application/pdf	-
dc.language	en_US	-
dc.relation	Molecular Engineering of Biological and Chemical Systems (MEBCS);	-
dc.subject	poly(2-N-(dimethylaminoethyl) methacrylate) Pluronic®	-
dc.subject	cerium (IV)	-
dc.subject	free-radical polymerization	-
dc.subject	self-assembly	-
dc.subject	gene therapy	-
dc.title	Synthesis and Properties of Novel Cationic, Temperature-Sensitive Block-Copolymers	-
dc.type	Article	-
Appears in Collections:	MIT Items

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