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http://dspace.mediu.edu.my:8181/xmlui/handle/1721.1/3951Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.creator | Tam, Michael K. C. | - |
| dc.date | 2003-12-16T14:29:04Z | - |
| dc.date | 2003-12-16T14:29:04Z | - |
| dc.date | 2004-01 | - |
| dc.date.accessioned | 2013-10-09T02:33:18Z | - |
| dc.date.available | 2013-10-09T02:33:18Z | - |
| dc.date.issued | 2013-10-09 | - |
| dc.identifier | http://hdl.handle.net/1721.1/3951 | - |
| dc.identifier.uri | http://koha.mediu.edu.my:8181/xmlui/handle/1721 | - |
| dc.description | This talk will focus on the development of polymeric nano-structured systems for drug and gene delivery applications. Two major classes of polymer systems will be considered; namely poly(ethylene-oxide-b-propylene-oxide-b-ethylene-oxide) (Pluronics) tri-block copolymers (FDA approved) and methacrylic acid (MAA) block and random copolymers. These polymers were functionalised with biodegradable or stimuli-sensitive functional groups to produce stimuli-sensitive nano-structure for efficient delivery of drugs and DNAs. The atom transfer radical polymerisation (ATRP) was adopted to synthesize a range of mono-dispersed block copolymers (e.g. PEO-b-MAA, MMA-b-MAA). Ring opening polymerization method was used to functionalize Pulronics with degradable functional groups, such as lactide (LA), and caprolactone (CL). Other stimuli-sensitive functional groups such as methacrylic acid was used to impart pH sensitivity to the polymers. Various types of methacrylic acid block and random cross-linked copolymers and other novel systems, such as fullerene based block copolymers were synthesized. Detailed mechanism and physics that control the micellization, microstructure and drug/polymer interactions will be discussed. | - |
| dc.description | Singapore-MIT Alliance (SMA) | - |
| dc.format | 12331 bytes | - |
| dc.format | application/pdf | - |
| dc.language | en_US | - |
| dc.relation | Molecular Engineering of Biological and Chemical Systems (MEBCS); | - |
| dc.subject | drug and gene delivery applications | - |
| dc.subject | stimuli responsive polymers | - |
| dc.title | Stimuli Responsive Polymers for Enhanced Drug Release Applications | - |
| dc.type | Article | - |
| Appears in Collections: | MIT Items | |
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