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http://dspace.mediu.edu.my:8181/xmlui/handle/1721.1/3791| Title: | Self-Assembled Coatings for Controlling Biomolecular Adsorption on Surfaces |
| Keywords: | polymer coatings protein adsorption surface modification thin films |
| Issue Date: | 9-Oct-2013 |
| Description: | We have investigated a series of molecular and polymeric approaches for generating adherent thin films that impart anti-fouling characteristics to oxide surfaces. These films incorporate oligo- or poly(ethylene glycol) moieties that are expressed in high density in the near-surface region. In our molecular approach, oligo(ethylene glycol)-terminated n-alkyl-trichlorosilanes, RO(CH₂CH₂O)₃(CH₂)₁₁SiCl₃, have been designed so to spontaneously adsorb onto oxide surfaces and produce densely packed films. Another strategy uses a surface initiated polymerization to generate reactive anchored polymer chains that are then chemically modified to incorporate oligo(ethylene glycol) units. Lastly, a comb copolymer comprising a poly(acrylic acid) backbone and different grafting ratios of a linear poly(ethylene oxide-r-propylene oxide) chain has been prepared that adsorbs onto surfaces and forms a poly(ethylene glycol)-exposing film in single step. These surface coatings provide varying levels of protein and cellular resistance that can be related to molecular-scale elements of their surface structure. Singapore-MIT Alliance (SMA) |
| URI: | http://koha.mediu.edu.my:8181/xmlui/handle/1721 |
| Other Identifiers: | http://hdl.handle.net/1721.1/3791 |
| Appears in Collections: | MIT Items |
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