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http://dspace.mediu.edu.my:8181/xmlui/handle/123456789/5923| Title: | Ivabradine, a novel heart rate slower: Is it a sword of double blades in patients with idiopathic dilated cardiomyopathy? |
| Keywords: | Ivabradine dilated cardiomyopathy heart failure safety efficacy |
| Issue Date: | 30-May-2013 |
| Publisher: | Aves Yayincilik |
| Description: | Objective: To prospectively assess the safety and efficacy of ivabradine in patients with idiopathic dilated cardiomyopathy.Methods: We included 35 patients with idiopathic dilated cardiomyopathy with an ejection fraction (EF) <40% and heart rate >70 beats/min despite optimal medical therapy, according to the international guidelines in this prospective, non-randomized, single-arm, open-label safety study. Ivabradine was used as an add-on therapy to the maximally tolerated b-blocker in an increasing titrated dose till a target dose of 15 mg/day or resting heart rate of 60 beats/min for 3 months. During follow-up period the safety, patient tolerance and efficacy of this drug were assessed. All patients underwent 12-lead resting electrocardiography and Holter monitoring at inclusion and after 3 months. Statistical analysis was accomplished using paired t-test and Pearson correlation analysis.Results: We found a significant reduction in the resting heart rate by a mean of 25.9±9.4%, without a significant change of blood pressure. There was no prolongation of PR, QTc or QRS durations. Ventricular ectopic activity showed significant reduction (p<0.001). There was a significant correlation between the resting heart rate, NYHA and left ventricular ejection fraction (p<0.001 for both). One patient developed photopsia and decompensation was observed in another patient. Conclusion: Ivabradine is a safe and effective drug in reducing resting heart rate, improving NYHA functional class without undesirable effects on conduction parameters or ectopic activity. |
| URI: | http://koha.mediu.edu.my:8181/jspui/handle/123456789/5923 |
| Other Identifiers: | http://anakarder.com/yazilar.asp?yaziid=2063&sayiid= http://www.doaj.org/doaj?func=openurl&genre=article&issn=13028723&date=2011&volume=11&issue=05&spage=402 |
| Appears in Collections: | Health Sciences |
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