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http://dspace.mediu.edu.my:8181/xmlui/handle/123456789/4050Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.creator | Franck Dufour | - |
| dc.creator | Wei-Qin Zhao | - |
| dc.creator | Lakshmi Ravindranath | - |
| dc.creator | Daniel L. Alkon | - |
| dc.date | 2003 | - |
| dc.date.accessioned | 2013-05-30T10:16:28Z | - |
| dc.date.available | 2013-05-30T10:16:28Z | - |
| dc.date.issued | 2013-05-30 | - |
| dc.identifier | http://neurobiologyoflipids.org/content/1/7/ | - |
| dc.identifier | http://www.doaj.org/doaj?func=openurl&genre=article&issn=16835506&date=2003&volume=1&issue=&spage=34 | - |
| dc.identifier.uri | http://koha.mediu.edu.my:8181/jspui/handle/123456789/4050 | - |
| dc.description | Cholesterol has recently received attention as a potentially important factor in Alzheimer's disease (AD) etiology. Caveolin, which binds cholesterol, plays a prominent role in cellular cholesterol transport. Here, we found a higher level of cholesterol and caveolin in the caveolae-enriched fractions prepared from AD patients' fibroblasts compared with age and sex matched controls (AC). Furthermore, the cross-linking activation of the prion protein, which is known to link to signal transduction of caveolin, is altered in AD fibroblasts. Our results suggest a dysregulation of cholesterol processing in AD fibroblasts which may contribute to the pathogenesis of AD. | - |
| dc.publisher | Neurobiology of Lipids | - |
| dc.source | Neurobiology of Lipids | - |
| dc.subject | Alzheimer's disease | - |
| dc.subject | amyloid beta precursor | - |
| dc.subject | APP | - |
| dc.subject | Down syndrome | - |
| dc.subject | etiology | - |
| dc.subject | lipids | - |
| dc.subject | lipoprotein | - |
| dc.subject | neurodegeneration marker | - |
| dc.subject | secretase | - |
| dc.subject | caveolin | - |
| dc.subject | caveolae | - |
| dc.subject | membrane | - |
| dc.subject | cell culture | - |
| dc.subject | human | - |
| dc.subject | non-neuronal tissue | - |
| dc.subject | neurodegenerative disease | - |
| dc.subject | signal transduction | - |
| dc.subject | prion | - |
| dc.subject | PKC | - |
| dc.subject | cross-linking | - |
| dc.subject | fractioning | - |
| dc.subject | biochemistry | - |
| dc.subject | triton | - |
| dc.title | Abnormal cholesterol processing in Alzheimer's disease patient's fibroblasts | - |
| Appears in Collections: | Biology and Life Sciences | |
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