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http://dspace.mediu.edu.my:8181/xmlui/handle/10419/4239| Title: | Optimal sequencing of antiretroviral drug cocktails under uncertainty and irreversibility |
| Keywords: | D81 H51 I12 ddc:330 HIV/AIDS Real option theory Cost-effectiveness analysis Combination therapy Developing countries AIDS Pharmazeutisches Produkt Kosten-Wirksamkeits-Analyse Realoption Entwicklungsländer |
| Issue Date: | 16-Oct-2013 |
| Publisher: | Kiel Institute for the World Economy (IfW) Kiel |
| Description: | This paper develops a real options approach to the optimal sequencing of antiretroviral drug cocktails for HIV/AIDS patients in resource-poor settings. The analysis focuses on the implications of endogenous resistance mutations in the virus that reduce or eliminate the effectiveness of individual drugs within a cocktail when lack of laboratory equipment prevents these from being identified. Using a model with two drug cocktails, we show that the first-line therapy should be introduced later than in the case without resistance mutations and that the second-line therapy should be introduced earlier. We go on to discuss implications for comparative cost-effectiveness analyses. |
| URI: | http://koha.mediu.edu.my:8181/xmlui/handle/10419/4239 |
| Other Identifiers: | http://hdl.handle.net/10419/4239 ppn:560065523 |
| Appears in Collections: | EconStor |
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