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Please use this identifier to cite or link to this item: http://dspace.mediu.edu.my:8181/xmlui/handle/10261/3589
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dc.creatorSanz, Libia-
dc.creatorBazaa, Amine-
dc.creatorMarrakchi, Naziha-
dc.creatorPérez, Alicia-
dc.creatorChenik, Mehdi-
dc.creatorBel Lasfer, Zakaria-
dc.creatorEl Ayeb, Mohamed-
dc.creatorCalvete, Juan J.-
dc.date2008-04-15T11:42:48Z-
dc.date2008-04-15T11:42:48Z-
dc.date2006-03-28-
dc.date.accessioned2017-01-31T01:02:19Z-
dc.date.available2017-01-31T01:02:19Z-
dc.identifierBiochem J. 2006 April 15; 395(Pt 2): 385–392-
dc.identifier1470-8728-
dc.identifierhttp://hdl.handle.net/10261/3589-
dc.identifier10.1042/BJ20051678-
dc.identifier.urihttp://dspace.mediu.edu.my:8181/xmlui/handle/10261/3589-
dc.descriptionCopyright © by Portland Press. The final version of record is available at http://www.biochemj.org/bj/default.htm-
dc.descriptionWe report the cloning and sequence analysis of Cerastes vipera and Macrovipera lebetina transmediterranea cDNAs coding for short non-RGD (Arg-Gly-Asp) disintegrins and for dimeric disintegrin subunits. The mRNAs belong to the short-coding class, suggesting that these disintegrin mRNAs may be more widely distributed than previously thought. Our data also argue for a common ancestry of the mRNAs of short disintegrins and those coding for precursors of dimeric disintegrin chains. The Macrovipera lebetina transmediterranea dimeric disintegrin reported to inhibit the laminin-binding integrins α3β1, α6β1 and α7β1 was analysed using a proteomic approach and was shown to bear MLD (Met-Leu-Asp) and VGD (Val-Gly-Asp) motifs. The results highlight the fact that disintegrins have evolved a restricted panel of integrin-blocking sequences that segregate with defined branches of the phylogenetic tree of the integrin α-chains, providing novel insights into the evolutionary adaptation of the snake venom antagonists to the ligand-binding sites of their target integrin receptors.-
dc.descriptionThis study has been partly financed by grant BFU2004-01432/BMC from the Ministerio de Educación y Ciencia, Madrid, Spain, and by the Spanish–Tunisian Cooperation Programme 29p/02 from the Agencia Española de Cooperación Internacional (AECI).-
dc.descriptionPeer reviewed-
dc.format763802 bytes-
dc.formatapplication/pdf-
dc.languageeng-
dc.publisherBiochemical Society-
dc.rightsopenAccess-
dc.subjectCerastes vipera-
dc.subjectMacrovipera lebetina transmediterranea-
dc.subjectIntegrin inhibition-
dc.subjectSnake venom disintegrin-
dc.subjectSnake venomics-
dc.subjectToxin evolution-
dc.titleMolecular cloning of disintegrins from Cerastes vipera and Macrovipera lebetina transmediterranea venom gland cDNA libraries: insight into the evolution of the snake venom integrin-inhibition system-
dc.typeArtículo-
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