Transplanted long-term cultured pre-BI cells expressing calpastatin are resistant to B cell receptor–induced apoptosis

Please use this identifier to cite or link to this item: http://dspace.mediu.edu.my:8181/xmlui/handle/10261/3420

Title:	Transplanted long-term cultured pre-BI cells expressing calpastatin are resistant to B cell receptor–induced apoptosis
Keywords:	pre-B cells Calpastatin Calpain BCR Transplant
Publisher:	Rockefeller University Press
Description:	Copyright © by The Rockefeller University Press Long-term cultured pre-B cells are able to differentiate into immunoglobulin (Ig)M-positive B cells (IgM cells) when transplanted into severe combined immunodeficient (SCID) mice. Based on previous studies, here we report the development of a reconstitution assay in nonobese diabetic/SCID (NOD/SCID) mice using pre-B cells, which allows us to study the role of calpains (calcium-activated endopeptidases) during B cell development as well as in B cell clonal deletion. Using this model, we show that calpastatin (the natural inhibitor of calpains) inhibits B cell receptor–induced apoptosis in IgM cells derived from transplanted mice. We thus hypothesize an important function for calpain in sculpting the B cell repertoire. Peer reviewed
URI:	http://dspace.mediu.edu.my:8181/xmlui/handle/10261/3420
Other Identifiers:	The Journal of Experimental Medicine, volume 194, number 3, august 6, 2001, pp. 247–254 0022-1007 http://hdl.handle.net/10261/3420
Appears in Collections:	Digital Csic

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