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http://dspace.mediu.edu.my:8181/xmlui/handle/10261/3420Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.creator | Ruíz Vela, Antonio | - |
| dc.creator | Serrano Gómez, Fernando | - |
| dc.creator | González de la Peña, Manuel Angel | - |
| dc.creator | Abad, José Luis | - |
| dc.creator | Bernad, Antonio | - |
| dc.creator | Maki, Masatoshi | - |
| dc.creator | Martínez-Alonso, Carlos | - |
| dc.date | 2008-04-02T11:47:16Z | - |
| dc.date | 2008-04-02T11:47:16Z | - |
| dc.date | 2001-08 | - |
| dc.date.accessioned | 2017-01-31T01:01:26Z | - |
| dc.date.available | 2017-01-31T01:01:26Z | - |
| dc.identifier | The Journal of Experimental Medicine, volume 194, number 3, august 6, 2001, pp. 247–254 | - |
| dc.identifier | 0022-1007 | - |
| dc.identifier | http://hdl.handle.net/10261/3420 | - |
| dc.identifier.uri | http://dspace.mediu.edu.my:8181/xmlui/handle/10261/3420 | - |
| dc.description | Copyright © by The Rockefeller University Press | - |
| dc.description | Long-term cultured pre-B cells are able to differentiate into immunoglobulin (Ig)M-positive B cells (IgM cells) when transplanted into severe combined immunodeficient (SCID) mice. Based on previous studies, here we report the development of a reconstitution assay in nonobese diabetic/SCID (NOD/SCID) mice using pre-B cells, which allows us to study the role of calpains (calcium-activated endopeptidases) during B cell development as well as in B cell clonal deletion. Using this model, we show that calpastatin (the natural inhibitor of calpains) inhibits B cell receptor–induced apoptosis in IgM cells derived from transplanted mice. We thus hypothesize an important function for calpain in sculpting the B cell repertoire. | - |
| dc.description | Peer reviewed | - |
| dc.format | 455975 bytes | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Rockefeller University Press | - |
| dc.rights | openAccess | - |
| dc.subject | pre-B cells | - |
| dc.subject | Calpastatin | - |
| dc.subject | Calpain | - |
| dc.subject | BCR | - |
| dc.subject | Transplant | - |
| dc.title | Transplanted long-term cultured pre-BI cells expressing calpastatin are resistant to B cell receptor–induced apoptosis | - |
| dc.type | Artículo | - |
| Appears in Collections: | Digital Csic | |
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