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http://dspace.mediu.edu.my:8181/xmlui/handle/10261/3386| Title: | Role of the PI3K regulatory subunit in the control of actin organization and cell migration |
| Keywords: | N-WASP Cdc42 PDGF Phosphatidylinositol 3-kinase Actin cytoskeleton |
| Publisher: | Rockefeller University Press |
| Description: | Copyright © by The Rockefeller University Press Cell migration represents an important cellular response that utilizes cytoskeletal reorganization as its driving force. Here, we describe a new signaling cascade linking PDGF receptor stimulation to actin rearrangements and cell migration. We demonstrate that PDGF activates Cdc42 and its downstream effector N-WASP to mediate filopodia formation, actin stress fiber disassembly, and a reduction in focal adhesion complexes. Induction of the Cdc42 pathway is independent of phosphoinositide 3-kinase (PI3K) enzymatic activity, but it is dependent on the p85 a regulatory subunit of PI3K. Finally, data are provided showing that activation of this pathway is required for PDGF-induced cell migration on collagen. These observations show the essential role of the PI3K regulatory subunit p85 a in controlling PDGF receptor–induced cytoskeletal changes and cell migration, illustrating a novel signaling pathway that links receptor stimulation at the cell membrane with actin dynamics Peer reviewed |
| URI: | http://dspace.mediu.edu.my:8181/xmlui/handle/10261/3386 |
| Other Identifiers: | The Journal of Cell Biology, volume 151, number 2, october 16, 2000, pp. 249–261 0021-9525 http://hdl.handle.net/10261/3386 |
| Appears in Collections: | Digital Csic |
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