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http://dspace.mediu.edu.my:8181/xmlui/handle/10261/3386Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.creator | Jiménez, Concepción | - |
| dc.creator | Armas Portela, Rosario | - |
| dc.creator | Mellado, Mario | - |
| dc.creator | Rodríguez Frade, José M. | - |
| dc.creator | Collard, John | - |
| dc.creator | Serrano, Antonio | - |
| dc.creator | Martínez-Alonso, Carlos | - |
| dc.creator | Ávila, Jesús | - |
| dc.creator | Carrera, Ana C. | - |
| dc.date | 2008-03-31T09:59:06Z | - |
| dc.date | 2008-03-31T09:59:06Z | - |
| dc.date | 2000-10 | - |
| dc.date.accessioned | 2017-01-31T01:01:21Z | - |
| dc.date.available | 2017-01-31T01:01:21Z | - |
| dc.identifier | The Journal of Cell Biology, volume 151, number 2, october 16, 2000, pp. 249–261 | - |
| dc.identifier | 0021-9525 | - |
| dc.identifier | http://hdl.handle.net/10261/3386 | - |
| dc.identifier.uri | http://dspace.mediu.edu.my:8181/xmlui/handle/10261/3386 | - |
| dc.description | Copyright © by The Rockefeller University Press | - |
| dc.description | Cell migration represents an important cellular response that utilizes cytoskeletal reorganization as its driving force. Here, we describe a new signaling cascade linking PDGF receptor stimulation to actin rearrangements and cell migration. We demonstrate that PDGF activates Cdc42 and its downstream effector N-WASP to mediate filopodia formation, actin stress fiber disassembly, and a reduction in focal adhesion complexes. Induction of the Cdc42 pathway is independent of phosphoinositide 3-kinase (PI3K) enzymatic activity, but it is dependent on the p85 a regulatory subunit of PI3K. Finally, data are provided showing that activation of this pathway is required for PDGF-induced cell migration on collagen. These observations show the essential role of the PI3K regulatory subunit p85 a in controlling PDGF receptor–induced cytoskeletal changes and cell migration, illustrating a novel signaling pathway that links receptor stimulation at the cell membrane with actin dynamics | - |
| dc.description | Peer reviewed | - |
| dc.format | 804197 bytes | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Rockefeller University Press | - |
| dc.rights | openAccess | - |
| dc.subject | N-WASP | - |
| dc.subject | Cdc42 | - |
| dc.subject | PDGF | - |
| dc.subject | Phosphatidylinositol 3-kinase | - |
| dc.subject | Actin cytoskeleton | - |
| dc.title | Role of the PI3K regulatory subunit in the control of actin organization and cell migration | - |
| dc.type | Artículo | - |
| Appears in Collections: | Digital Csic | |
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