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http://dspace.mediu.edu.my:8181/xmlui/handle/10261/3282Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.creator | Esplugues, Enric | - |
| dc.creator | Sancho, David | - |
| dc.creator | Vega-Ramos, Javier | - |
| dc.creator | Martínez-Alonso, Carlos | - |
| dc.creator | Syrbe, Uta | - |
| dc.creator | Hamann, Alf | - |
| dc.creator | Engel, Pablo | - |
| dc.creator | Sánchez Madrid, Francisco | - |
| dc.creator | Lauzurica, Pilar | - |
| dc.date | 2008-03-25T07:56:32Z | - |
| dc.date | 2008-03-25T07:56:32Z | - |
| dc.date | 2003-05 | - |
| dc.date.accessioned | 2017-01-31T01:00:53Z | - |
| dc.date.available | 2017-01-31T01:00:53Z | - |
| dc.identifier | The Journal of Experimental Medicine, Volume 197, Number 9, May 5, 2003, pp. 1093–1106 | - |
| dc.identifier | 0022-1007 | - |
| dc.identifier | http://hdl.handle.net/10261/3282 | - |
| dc.identifier | 10.1084/jem.20021337 | - |
| dc.identifier.uri | http://dspace.mediu.edu.my:8181/xmlui/handle/10261/3282 | - |
| dc.description | Copyright © by The Rockefeller University Press | - |
| dc.description | We investigated the in vivo role of CD69 by analyzing the susceptibility of CD69 / mice to tumors. CD69 / mice challenged with MHC class I tumors (RMA-S and RM-1) showed greatly reduced tumor growth and prolonged survival compared with wild-type (WT) mice. The enhanced anti–tumor response was NK cell and T lymphocyte–mediated, and was due, at least in part, to an increase in local lymphocytes. Resistance of CD69 / mice to MHC class I tumor growth was also associated with increased production of the chemokine MCP-1, diminished TGF- production, and decreased lymphocyte apoptosis. Moreover, the in vivo blockade of TGF- in WT mice resulted in enhanced anti–tumor response. In addition, CD69 engagement induced NK and T cell production of TGF- , directly linking CD69 signaling to TGF- regulation. Furthermore, anti-CD69 antibody treatment in WT mice induced a specific down-regulation in CD69 expression that resulted in augmented anti–tumor response. These data unmask a novel role for CD69 as a negative regulator of anti–tumor responses and show the possibility of a novel approach for the therapy of tumors. | - |
| dc.description | Peer reviewed | - |
| dc.format | 263366 bytes | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Rockefeller University Press | - |
| dc.rights | openAccess | - |
| dc.subject | Cytokines | - |
| dc.subject | Homeostasis | - |
| dc.subject | Apoptosis | - |
| dc.title | Enhanced Antitumor Immunity in Mice Deficient in CD69 | - |
| dc.type | Artículo | - |
| Appears in Collections: | Digital Csic | |
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