1. DSpace at MEDIU
  2. Harvested articles مقالات مستوردة من مؤسسات وجامعات عالمية
  3. Digital Csic
Please use this identifier to cite or link to this item: http://dspace.mediu.edu.my:8181/xmlui/handle/10261/2973
Full metadata record
DC FieldValueLanguage
dc.creatorCasanovas, Josep M.-
dc.creatorLesourd, Monique-
dc.creatorArtigas, Francesc-
dc.date2008-02-18T18:27:14Z-
dc.date2008-02-18T18:27:14Z-
dc.date1997-10-
dc.date.accessioned2017-01-31T01:00:11Z-
dc.date.available2017-01-31T01:00:11Z-
dc.identifierBritish Journal of Pharmacology 122(4): 733–741 (1997)-
dc.identifier0007-1188-
dc.identifierhttp://hdl.handle.net/10261/2973-
dc.identifier10.1038/sj.bjp.0701420-
dc.identifier.urihttp://dspace.mediu.edu.my:8181/xmlui/handle/10261/2973-
dc.description1. We have examined the effects of the systemic administration of the selective 5-HT1A agonist alnespirone (S-20499) on in vivo 5-hydroxytryptamine (5-HT) release in the dorsal raphe nucleus, the median raphe nucleus and four forebrain areas innervated differentially by both (dorsal striatum, frontal cortex, ventral hippocampus and dorsal hippocampus).-
dc.description2. Alnespirone (0.1–3mgkg−1, s.c.) dose-dependently reduced extracellular 5-HT in the six areas examined. In forebrain, the maximal reductions occurred in striatum and frontal cortex (maximal reduction to 23 and 29% of baseline, respectively). Those in dorsal and ventral hippocampus were more moderate (to ca 65% of baseline). In contrast, the decrease in 5-HT elicited in the median raphe nucleus was more marked than that in the dorsal raphe nucleus (to ca 30 and 60% of baseline, respectively). The selective 5-HT1A antagonist WAY-100635 (0.5mgkg−1, s.c.) prevented the decrease in 5-HT induced by alnespirone (0.3mgkg−1, s.c.) in frontal cortex.-
dc.description3. 8-OH-DPAT (0.025, 0.1 and 0.3mgkg−1, s.c.) also reduced extracellular 5-HT in a regionally-selective manner (e.g., to 32% of baseline in striatum and to 69% in dorsal hippocampus at 0.1mgkg−1, s.c.). In midbrain, 8-OH-DPAT reduced the dialysate 5-HT slightly more in the median than in the dorsal raphe nucleus at all doses examined.-
dc.description4. Doses of both compounds close to their respective ED50 values (0.3mgkg−1 alnespirone, 0.025mgkg−1 8-OH-DPAT) reduced 5-HT to a comparable extent in all regions examined. However, the reductions attained at higher doses were more pronounced for 8-OH-DPAT.-
dc.description5. These data show that the reduction of 5-HT release elicited by alnespirone and 8-OH-DPAT is more important in forebrain areas innervated by 5-hydroxytryptaminergic neurones of the dorsal raphe nucleus. This regional selectivity seems unlikely to be accounted for by differences in the sensitivity of 5-HT1A autoreceptors controlling 5-HT release, given the dissimilar effects of these two 5-HT1A agonists in regions rich in cell bodies and nerve terminals. This suggests the presence of complex mechanisms of control of 5-HT release by 5-HT1A receptors.-
dc.descriptionThis work was supported by grants from the Institut de Recherches Internationales Servier and Fondo de Investigación Sanitaria (FIS 95/266).-
dc.descriptionPeer reviewed-
dc.format394539 bytes-
dc.formatapplication/pdf-
dc.languageeng-
dc.publisherBritish Pharmacological Society-
dc.relationhttp://dx.doi.org/10.1038/sj.bjp.0701420-
dc.rightsopenAccess-
dc.subject5-Hydroxytryptamine (5-HT) release-
dc.subject5-Hydroxytryptamine1A agonists-
dc.subjectAntidepressants-
dc.subjectDorsal raphe nucleus-
dc.subjectDorsal striatum-
dc.subjectHippocampus-
dc.subjectMedian raphe nucleus-
dc.subjectMicrodialysis-
dc.titleThe effect of the selective 5-HT1A agonists alnespirone (S-20499) and 8-OH-DPAT on extracellular 5-hydroxytryptamine in different regions of rat brain-
dc.typeArtículo-
Appears in Collections:Digital Csic

Files in This Item:
There are no files associated with this item.
Show simple item record


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.