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http://dspace.mediu.edu.my:8181/xmlui/handle/10261/2832| Title: | Characterization of in vivo MRI detectable thalamic amyloide plaques from APP/PS1 mice |
| Keywords: | Alzheimer’s disease Animal models Amyloid Transgenic mouse |
| Publisher: | Elsevier |
| Description: | Amyloid deposits are one of the hallmarks of Alzheimer’s disease. Recent studies, in transgenic mice modeling Alzheimer’s disease showed
that, using in vivo, contrast agent-free, MRI, thalamic amyloid plaques are more easily detected than other plaques of the brain. Our study
evaluated the characteristics of these thalamic plaques in a large population of APP/PS1, PS1 and C57BL/6 mice. Thalamic spots were detected
in all mice but with different frequency and magnitude. Hence, the prevalence and size of the lesions were higher in APP/PS1 mice. However,
even in APP/PS1 mice, thalamic spots did not occur in all the old animals. In APP/PS1 mice, spots detection was related to high iron and
calcium load within amyloid plaques and thus reflects the ability of such plaque to capture large amounts of minerals. Interestingly, calcium
and iron was also detected in extra-thalamic plaques but with a lower intensity. Hypointense lesions in the thalamus were not associated with
the iron load in the tissue surrounding the plaques, nor with micro-hemorrhages, inflammation, or a neurodegenerative context. Peer reviewed |
| URI: | http://dspace.mediu.edu.my:8181/xmlui/handle/10261/2832 |
| Other Identifiers: | Neurobiology of Aging 30(1): 41-53(2007) http://hdl.handle.net/10261/2832 10.1016/neurobiolaging.207.05.018 |
| Appears in Collections: | Digital Csic |
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