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http://dspace.mediu.edu.my:8181/xmlui/handle/10261/1980| Title: | Synthesis, inhibition properties and theoretical study of the new nanomolar trehalase inhibitor 1-thiatrehazolin: Towards a structural understanding of trehazolin inhibition |
| Keywords: | Ab initio calculations Cyclitols Glycosidases Inhibitors Sulfur heterocycles |
| Publisher: | John Wiley & Sons |
| Description: | 6 páginas, 2 figuras, 2 esquemas, 2 tablas.-- ChemBioChem Special Issue: EMBO Symposium: Chemistry Meets Biology. A new trehazolin analogue, 1-thiatrehazolin, has been synthesized from carbohydrate precursors by a highly efficient route based on our previously developed ketone/oxime ether reductive carbocyclization reaction for the construction of the cyclitol ring and an intramolecular nucleophilic displacement reaction for the construction of the thiazoline ring. 1-Thiatrehazolin is a very potent, slow, tight-binding trehalase inhibitor. On the basis of the experimental results, a structural model for trehalase inhibition by trehazolin and analogues is proposed, supported by theoretical calculations. Financial support by the Ministry of Science and Technology of Spain (project BQU2000-1501-C02-01) is gratefully acknowledged. Peer reviewed |
| URI: | http://dspace.mediu.edu.my:8181/xmlui/handle/10261/1980 |
| Other Identifiers: | ChemBioChem 6(1): 186-191 (2005) 10.1002/cbic.200400231 http://hdl.handle.net/10261/1980 10.1002/cbic.200400231 |
| Appears in Collections: | Digital Csic |
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