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http://dspace.mediu.edu.my:8181/xmlui/handle/10261/1980Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.creator | Chiara, José Luis | - |
| dc.creator | Storch, Isabel | - |
| dc.creator | García, Ángela | - |
| dc.creator | Bastida, Ágatha | - |
| dc.creator | Bobo, Sofía | - |
| dc.creator | Martín-Ortega, María D. | - |
| dc.date | 2007-11-12T11:11:00Z | - |
| dc.date | 2007-11-12T11:11:00Z | - |
| dc.date | 2004-11-08 | - |
| dc.date.accessioned | 2017-01-31T00:58:17Z | - |
| dc.date.available | 2017-01-31T00:58:17Z | - |
| dc.identifier | ChemBioChem 6(1): 186-191 (2005) | - |
| dc.identifier | 10.1002/cbic.200400231 | - |
| dc.identifier | http://hdl.handle.net/10261/1980 | - |
| dc.identifier | 10.1002/cbic.200400231 | - |
| dc.identifier.uri | http://dspace.mediu.edu.my:8181/xmlui/handle/10261/1980 | - |
| dc.description | 6 páginas, 2 figuras, 2 esquemas, 2 tablas.-- ChemBioChem Special Issue: EMBO Symposium: Chemistry Meets Biology. | - |
| dc.description | A new trehazolin analogue, 1-thiatrehazolin, has been synthesized from carbohydrate precursors by a highly efficient route based on our previously developed ketone/oxime ether reductive carbocyclization reaction for the construction of the cyclitol ring and an intramolecular nucleophilic displacement reaction for the construction of the thiazoline ring. 1-Thiatrehazolin is a very potent, slow, tight-binding trehalase inhibitor. On the basis of the experimental results, a structural model for trehalase inhibition by trehazolin and analogues is proposed, supported by theoretical calculations. | - |
| dc.description | Financial support by the Ministry of Science and Technology of Spain (project BQU2000-1501-C02-01) is gratefully acknowledged. | - |
| dc.description | Peer reviewed | - |
| dc.language | eng | - |
| dc.publisher | John Wiley & Sons | - |
| dc.relation | http://dx.doi.org/10.1002/cbic.200400231 | - |
| dc.rights | openAccess | - |
| dc.subject | Ab initio calculations | - |
| dc.subject | Cyclitols | - |
| dc.subject | Glycosidases | - |
| dc.subject | Inhibitors | - |
| dc.subject | Sulfur heterocycles | - |
| dc.title | Synthesis, inhibition properties and theoretical study of the new nanomolar trehalase inhibitor 1-thiatrehazolin: Towards a structural understanding of trehazolin inhibition | - |
| dc.type | Artículo | - |
| Appears in Collections: | Digital Csic | |
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